Year: 2016
Type: article
Abstract: Background: Hydrogen has been demonstrated can selec vely reduce the hydroxyl, which is the main cause of ionizing radia on-induced damage.Amifos ne (AM) is the only radioprotec ve drug approved by the U.S. Food and Drug Administra on for use in radiotherapy.The purpose of the present study was to inves gate the combined radio-protec ve effect of hydrogen rich water (HRW) and AM. Materials and Methods: Male ICR mice were treated intragastrically with HRW or/and intraperitoneally with AM 30 minutes prior to 9.0 Gy whole body irradia on from a 60 Co source (dose rate 0.96Gy/min).Then the survival rate for 30 days, the hematological parameters, the Clinical chemistry parameters and the bone marrow nucleated cells were examined.Results: We found that the mice treated with HRW and AM before irradia on could increase the 30-day survival rate and improve the body weight be2er than the HRW or AM treatment alone group and irradia on alone group.Hematological test and Clinical chemistry assays also showed the same results that HRW combined AM could be2er improve the recovery of hemopoie c system and alleviate the detrimental effects of radia on.Conclusion: The results indicate that the combined applica on of HRW and AM may be a be2er method for radia on therapy.
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W2514157330