Work

Genetic engineering of Catharanthus roseus to enhance production of anticancer pharmaceutical compounds

Year: 2015

Type: dissertation

Abstract: The medicinal plant, Catharanthus roseus, is the source of pharmaceutically valuable anticancer alkaloids, vincristine (VCR) and vinblastine (VBL). These alkaloids are produced only in C. roseus and at extremely low levels (0.0002 wt%). Due to their low levels, the isolation of these compounds is both laborious and costly, ranging from $4 to $60 million/kg. Despite these barriers, these alkaloids have been effectively used to treat cancer for over 50 years.

DOI: 10.17760/d20194128

Author: Noreen F. Rizvi

Language: English

Topic: Plant tissue culture and regeneration

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Funders: National Science Foundation, American Association of University Women, Division of Chemical, Bioengineering, Environmental, and Transport Systems

Award: Transcriptional Control of Alkaloid Biosynthesis in Catharanthus roseus Cultures

OpenAlex ID: W2514477477

Cites: 92

Cited by: 1

Related to: 10