Degradable Terpolymers with Alkyl Side Chains Demonstrate Enhanced Gene Delivery Potency and Nanoparticle Stability
Year: 2013
Type: article
Abstract: Degradable, cationic poly(β-amino ester)s (PBAEs) with alkyl side chains are developed for non-viral gene delivery. Nanoparticles formed from these PBAE terpolymers exhibit significantly enhanced DNA transfection potency and resistance to aggregation. These hydrophobic PBAE terpolymers, but not PBAEs lacking alkyl side chains, support interaction with PEG-lipid conjugates, facilitating their functionalization with shielding and targeting moieties and accelerating the in vivo translation of these materials.
Source: Advanced Materials
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Awards: High-Throughput Craniofacial tissue engineering, G1146287700, Controlled Release of Macromolecules, G1505915345, G3665912897, G3745596555, Targeted Nanoparticle DNA Therapy for Ovarian Cancer, A new high-throughput gastrointestinal tract explant platform for drug formulation discovery and metabolic disease modulation, G5315489926, G5797641063, G6632036768, Cancer Center Support (Core) Grant
OpenAlex ID: W2108251247