Tongue worm ( Linguatula species) in stray dogs imported into the UK
Year: 2016
Type: article
Abstract: Epidemiological and modelling studies suggest that elimination of Onchocerca volvulus transmission (EoT) throughout Africa may not be achievable with annual mass drug administration (MDA) of ivermectin alone, particularly in areas of high endemicity and vector density.Single-dose Phase II and III clinical trials demonstrated moxidectin's superiority over ivermectin for prolonged clearance of O. volvulus microfilariae.We used the stochastic, individual-based EPIONCHO-IBM model to compare the probabilities of reaching EoT between ivermectin and moxidectin MDA for a range of endemicity levels (30 to 70% baseline microfilarial prevalence), treatment frequencies (annual and biannual) and therapeutic coverage/adherence values (65 and 80% of total population, with, respectively, 5 and 1% of systematic non-adherence).EPIONCHO-IBM's projections indicate that biannual (six-monthly) moxidectin MDA can reduce by half the number of years necessary to achieve EoT in mesoendemic areas and might be the only strategy that can achieve EoT in hyperendemic areas.Data needed to improve modelling projections include (i) the effect of repeated annual
Source: Veterinary Record
DOI: 10.1136/vr.i4829
Authors: Sian Mitchell, Suzi Bell, Ian Wright, Richard Wall, Sonja Jeckel, Damer Blake, Penny Marshall, Ceri Andrews, Michelle Lee, Amanda Walsh
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2515547964