Year: 2009
Type: article
Abstract: Xiaocong ChenChronic ethanol feeding to mice and rats decreases serum adiponectin concentration and adiponectin treatment during chronic ethanol feeding attenuates ethanol-induced liver injury in mice.Here we have investigated the impact of chronic ethanol feeding on adiponectin expression and secretion by adipose tissue.Rats were fed a 36% Lieber-DeCarli ethanol-containing liquid diet or pair-fed control diet for 4 weeks.Chronic ethanol feeding decreased adiponectin mRNA, but had no effect on adiponectin protein, in subcutaneous adipose tissue.Chronic ethanol feeding also reduced adiponectin secretion by isolated subcutaneous adipocytes without affecting the intracellular adiponectin.Treatment with brefeldin A suppressed adiponectin secretion by subcutaneous adipocytes from pair-fed rats, but had little effect after ethanol feeding.In subcutaneous adipocytes from pair-fed rats, adiponectin was enriched in endoplasmic reticulum (ER)/Golgi relative to plasma membrane; however, after chronic ethanol feeding, adiponectin was equally distributed between plasma membrane and ER/Golgi fractions.These data suggested that chronic ethanol feeding decreased circulating adiponectin by inhibiting adiponectin and secretion by subcutaneous adipocytes.Chronic ethanol feeding increases oxidative stress and endoplasmic reticulum (ER) stress in adipose tissue.Here we hypothesized that supplemental taurine, an amino acid
Author: Xiaocong Chen
Institution: Case Western Reserve University
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2515658012