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Familial Haploidentical (FHI) Allogeneic Stem Cell Transplantation Utilizing CD34 Enrichment and T Cell Addback in Children, Adolescents & Adults with High-Risk Sickle Cell Disease. Rapid Engraftment, Low Incidence of Agvhd, and Sustained Donor Chimerism

Year: 2016
Type: article
Abstract: These preliminary results demonstrate the safety, feasibility and efficacy of FHI AlloSCT utilizing CD34 enrichment and T cell addback from parental SCD trait donors. All patients engrafted with a very low incidence of grade II-IV AGVHD, high sustained donor chimerism with an absence of SCD symptoms or organ complications in this high-risk SCD population. This research was supported by FDA grant 5R01FD004090 (IND 14359).Figure 1View Large Image Figure ViewerDownload Hi-res image Download (PPT)Figure 1. (continued).View Large Image Figure ViewerDownload Hi-res image Download (PPT)
DOI: 10.1016/j.bbmt.2015.11.876
Authors: Mitchell S. Cairo, Julie-An M. Talano, Theodore B. Moore, Rona Weinberg, Carolyn A. Keever-Taylor, Brenda Grossman, Lee Ann Baxter-Lowe, Susan K. Parsons, Suzanne Braniecki, Erin Morris, Phyllis Brand, Sandra Fabricatore, Janet Ayello, Mildred Semidei-Pomales, Carmella van de Ven, Cori Abikoff, Shalini Shenoy
Institutions: New York Medical College, Medical College of Wisconsin, University of California, Los Angeles, New York Blood Center, Washington University in St. Louis, University of Southern California, Children's Hospital Los Angeles, Tufts Medical Center, St. Louis Children's Hospital
Language: English
Subfield: Hematology
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2516219155
FWCI: 0.635
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Cited by: 2
Related to: 10