Long-Term Organ Function in Children Following Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease
Year: 2016
Type: article
Study design: Observational Study
Abstract: Long-term outcomes data for patients after hematopoietic stem cell transplant (HSCT) is lacking and even more so in the non-malignant pediatric population. Hence, we analyzed 22 children with Chronic Granulomatous Disease (CGD) that underwent HSCT between 2003-2015 from matched related donors (MRD, n=6), matched unrelated donors (MUD, n=12), or mismatched unrelated donors (MMUD 9/10, n=4). The median age at the time of transplant was 5.5 years (range: 0.5-17 years). Sixty percent of the patients had lung disease prior to transplant secondary to previous infections or lung resection.
Authors: Alexandra N. Cain, Imelda C. Hanson, Lisa Forbes, Filiz O. Seeborg, Lenora M. Noroski, Jordan Orange, Nicholas I. Rider, William Shearer, Kathryn Leung, Swati Naik, Stephen Gottschalk, Carl Allen, Nabil Ahmed, Ghadir Sasa, Bilal Omer, Ann M. Leen, Helen E. Heslop, Robert A. Krance, Caridad Martinez
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2516610719