Year: 2016
Type: review
Abstract: Macrophages are present in all tissues, either as resident cells or monocyte-derived cells that infiltrate into tissues. The tissue site largely determines the phenotype of tissue-resident cells, which help to maintain tissue homeostasis and act as sentinels of injury. Both tissue resident and recruited macrophages make a substantial contribution to wound healing following injury. In this review, we evaluate how macrophages in two fundamentally distinct tissues, i.e. the lung and the skin, differentially contribute to the process of wound healing. We highlight the commonalities of macrophage functions during repair and contrast them with distinct, tissue-specific functions that macrophages fulfill during the different stages of wound healing.
Language: English
Topic: Wound Healing and Treatments
Subfield: Rehabilitation
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,097
Awards: Use of EGF-R antagonists for the treatment of infections and tumour growth, G27278756, Chitinase-like proteins: Host protection through molecular multi-tasking., Chitinase-like proteins: Host protection through molecular multi-tasking., Macrophage provenance, proliferation and plasticity in nematode infection, G860769130, Macrophage provenance, proliferation and plasticity in nematode infection, G8810782723, G8812218988
OpenAlex ID: W2516952220