Hemodynamic Correlates of Blood Pressure in Older Adults: The Atherosclerosis Risk in Communities (ARIC) Study

Year: 2016

Type: article

Abstract: The primary aim of the present study was to identify the hemodynamic correlates of both steady and pulsatile blood pressure (BP) in community-dwelling older adults. In 3762 adults aged 70 to 89 years, significant hemodynamic determinants of both brachial and carotid systolic BP included arterial stiffness as measured by aortic pulse wave velocity, stroke volume (via echocardiography), arterial wave reflection, left ventricular ejection time, and upstroke time. The strongest influence was exerted by arterial stiffness. The steady-state component of blood pressure, mean arterial pressure, was associated with both cardiac index and total peripheral resistance (TPR), but was more strongly associated with TPR. Results were similar when participants taking antihypertensive medications were excluded from analyses. The overall findings suggest that mean arterial pressure is associated strongly with TPR and that significant hemodynamic correlates of systolic BP included arterial stiffness, stroke volume, and arterial wave reflection.

Source: Journal of Clinical Hypertension

DOI: 10.1111/jch.12898

Authors: Hirofumi Tanaka, Gerardo Heiss, Elizabeth L. McCabe, Michelle L. Meyer, Amil M. Shah, Judy R. Mangion, Justina Wu, Scott D. Solomon, Susan Cheng

Institutions: The University of Texas at Austin, University of North Carolina at Chapel Hill, Brigham and Women's Hospital, Harvard University

Language: English

Topic: Cardiovascular Health and Disease Prevention

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: American Heart Association, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences

OpenAlex ID: W2518022449