Work

Sphingolipids in spinal cord injury.

Year: 2016

Type: article

Abstract: Spinal cord injury (SCI) is a debilitating condition that affects millions of individuals worldwide. Despite progress over the last few decades, the molecular mechanisms of secondary SCI that continue to occur days and weeks after the original trauma remain poorly understood. As a result, current therapies for SCI are only marginally effective. Sphingolipids, a diverse class of bioactive lipids, have been shown to regulate SCI repair and key secondary injury processes such as apoptosis, ischemia and inflammation. This review will discuss the numerous roles of sphingolipids and highlight the potential of sphingolipid-targeted therapies for SCI.

Source: PubMed Central

Authors: Zachary B Jones, Yi Ren

Institutions: Florida State University, Wenzhou Medical University, First Affiliated Hospital of Wenzhou Medical University

Language: English

Topic: Spinal Cord Injury Research

Subfield: Clinical Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of General Medical Sciences

Awards: Statistical Methods for Ultrahigh-dimensional Biomedical Data, Quantitative Methods for Genome-wide Analysis of Macrophage Activation by ESCs