Serotherapy-Related Fevers, Blood Stream Infections (BSI), and Antibiotic Use in Pediatric Allogeneic Hematopoietic Cell Transplant (HCT) Recipients
Year: 2016
Type: article
Study design: Observational Study
Abstract: Serotherapy (ST) is a common component of allogeneic HCT conditioning regimens due to its immunomodulatory effects. Fevers and other allergic reactions are known to accompany ST use. Our standard procedure is to use empiric antibiotics in patients with fevers. We hypothesized that few ST-related fevers represent true BSI. We retrospectively collected data on 94 children receiving ST, including adverse events (AE), antibiotic use, and BSI until 60 days post HCT. All children were premedicated with corticosteroids, antihistamines and antipyretics.
Authors: Biljana Horn, Sara O'Kane, Rachel Wattier, Justin T. Wahlstrom, Alexis Melton, Morton J. Cowan, Christopher C. Dvorak
Institution: UCSF Benioff Children's Hospital
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2518500012