OC-0155: MR-guided multi-atlas based synthetic CT for MR-only radiotherapy of head and neck cancer patients
Year: 2016
Type: conference-abstract
Abstract: provided by dual-energy CT (DECT) compared to singleenergy CT (SECT) can be clinically used to reduce CT-based range uncertainties and to analyze intra-and interpatient tissue variations.First, a DECT scan protocol was optimized and clinically introduced.Second, in a first analysis patient DECT scans were evaluated concerning CT number variability. Material and Methods:After an experimental analysis of several CT scan settings concerning beam hardening, image quality and planned dose distribution using tissue surrogates, head and body phantoms and real tissues, an optimized and standardized DECT protocol (voltages: 80/140 kVp, kernel: D34) is clinically applied for patients treated with protons.45 planning and 360 control DECT scans of overall 70 patients were acquired with a single-source DECT scanner (Siemens SOMATOM Definition AS) until October 2015.Contouring and treatment planning are performed on pseudo-monoenergetic CT scans (MonoCT) derived by a weighted sum of both CT datasets.25 patients with different tumor sites (head, head & neck, prostate, pelvis) and overall 200 DECT scans were initially investigated to evaluate intra-and interpatient tissue variabilities.Based on the frequency distribution of voxelwise 80/140kVp CT number pairs, a linear correlation of low-density, soft and bony tissues can be determined, respectively.
Source: Radiotherapy and Oncology
Language: English
Subfield: Radiation
Field: Physics and Astronomy
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $3,770
OpenAlex ID: W2518656453