Year: 2015
Type: dissertation
Abstract: Low-molecular-weight (LMW) thiols play vital roles on a variety of cell metabolic pathways including oxidative stress management, xenobiotic detoxification, post-translational modification, and metal homeostasis. Previous studies have identified glutathione (GSH) as the dominant LMW thiol in eukaryotic cells as well as Gram-negative bacteria and mycothiol (MSH) as the dominant LMW thiol in Actinobacteria. Functional studies on those thiols have revealed their importance in cell metabolism, also their potential as target for antimicrobial development. Interestingly, neither GSH nor MSH was found in low G+C Gram-positive bacteria, including some notable pathogens, such as B. anthracis, B. cereus and S. aureus, etc. In 2009, a novel LMW thiol, bacillithiol (BSH), was identified in this class of bacteria and suggested to play analogous function as GSH and MSH.
Author: Fang, Zhong
Language: English
Topic: Sulfur Compounds in Biology
Subfield: Biochemistry
Domain: Life Sciences
Open Access status: green
Funder: National Science Foundation
OpenAlex ID: W2518754491