Work

Branch-Selective Hydroarylation: Iodoarene–Olefin Cross-Coupling

Year: 2016

Type: article

Abstract: A combination of cobalt and nickel catalytic cycles enables a highly branch-selective (Markovnikov) olefin hydroarylation. Radical cyclization and ring scission experiments are consistent with hydrogen atom transfer (HAT) generation of a carbon-centered radical that leads to engagement of a nickel cycle.

Source: Journal of the American Chemical Society

DOI: 10.1021/jacs.6b08507

Authors: Samantha A. Green, Jeishla L. M. Matos, Akiko Yagi, Ryan A. Shenvi

Institution: Scripps Research Institute

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500