Work

Incidence of Mucinous Metaplasia in the Prostate of FVB/N Mice (Mus musculus).

Year: 2016

Type: article

Abstract: Prostate epithelium in mice is considered to be relatively resistant to aged-related changes, as compared with human prostate epithelium, which is prone to spontaneous hyperplasia and cancer, for example. In addition, the incidence of metaplasia in mouse prostate typically is considered to be low. Here we report the incidence of mucinous metaplasia in the prostates of wild-type FVB/N mice. Our histologic study shows that mucinous metaplasia involving goblet cells occurs much more frequently (incidence as high as 50%) in the prostates of aged mice (17-24 mo) than has been reported previously. Mucinous metaplasia in the prostates of laboratory mice may be considerably more frequent than previously appreciated.

Source: PubMed

Authors: Leena Latonen, Paula Kujala, Tapio Visakorpi

Institutions: Tampere University Hospital, Fimlab (Finland), University of Tampere

Language: English

Topic: Urinary Bladder and Prostate Research

Subfield: Urology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2519926316

FWCI: 0.326

Cites: 13

Cited by: 2

Related to: 10