Maternal serum retinol and β-carotene concentrations and neonatal bone mineralization: results from the Southampton Women’s Survey cohort
Year: 2016
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Studies in older adults and animals have suggested contrasting relations between bone health and different vitamin A compounds. To our knowledge, the associations between maternal vitamin A status and offspring bone development have not previously been elucidated. OBJECTIVE: We examined the associations between maternal serum retinol and β-carotene concentrations during late pregnancy and offspring bone mineralization assessed at birth with the use of dual-energy X-ray absorptiometry. DESIGN: In the Southampton Women's Survey mother-offspring birth cohort, maternal health, lifestyle, and diet were assessed prepregnancy and at 11 and 34 wk of gestation. In late pregnancy, maternal serum retinol and β-carotene concentrations were measured. Offspring total body bone mineral density (BMD), bone mineral content (BMC), and bone area (BA) were measured within 2 wk after birth. RESULTS: In total, 520 and 446 mother-offspring pairs had measurements of maternal serum retinol and β-carotene, respectively. Higher maternal serum retinol in late pregnancy was associated with lower offspring total body BMC (β = -0.10 SD/SD; 95% CI: -0.19, -0.02; P = 0.020) and BA (β = -0.12 SD/SD; 95% CI: -0.20, -0.03; P = 0.009) but not BMD. Conversely, higher maternal serum β-carotene concentrations in late pregnancy were associated with greater total body BMC (β = 0.12 SD/SD; 95% CI: 0.02, 0.21; P = 0.016) and BA (β = 0.12 SD/SD; 95% CI: 0.03, 0.22; P = 0.010) but not BMD. CONCLUSIONS: Maternal serum retinol and β-carotene concentrations had differing associations with offspring bone size and growth at birth: retinol was negatively associated with these measurements, whereas β-carotene was positively associated. These findings highlight the need for further investigation of the effects of maternal retinol and carotenoid status on offspring bone development.
Institutions: University of Southern Denmark, Frederiksberg Hospital, Odense University Hospital, Bispebjerg Hospital, MRC Lifecourse Epidemiology Unit, Medical Research Council, Holbæk Sygehus, University of Copenhagen, National Institute of Public Health, National Health Service, University Hospital Southampton NHS Foundation Trust, NIHR Southampton Biomedical Research Centre, University of Southampton, National Institute for Health and Care Research, University of Oxford
Language: English
Subfield: Orthopedics and Sports Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,820
Awards: Vitamin D supplementation in pregnancy: A systematic review, G2890658772, NIHR Senior Investigator Award, G3720057038, NIHR Senior Investigator Award, G5932535539, G6219046052, Lifecourse Determinants of Bone and Joint Disease, NIHR Senior Investigator Award, Nutrition, Development and Lifelong Health: Studies in European Populations
OpenAlex ID: W2520308674