Year: 2013
Type: article
Abstract: Preclinical animal models serve as invaluable tools in the investigation of disease and the development of novel therapeutic strategies to prevent and treat disease.Osteosarcoma is the most common primary bone tumor in humans and dogs, and is associated with a high rate of lung metastasis.In order to successfully develop new strategies to improve outcomes for OSA patients, we sought to develop a clinically relevant mouse model with spontaneous metastasis.We successfully developed a model that mimicked the biologic behavior seen in dogs and in people with osteosarcoma.This included development of a primary bone tumor that was surgically amputated followed by development of lung metastasis.Lung metastases were quantified using stereological * *
Author: Beth K. Chaffee
Institution: The Ohio State University
Language: English
Topic: Veterinary Oncology Research
Subfield: Small Animals
Field: Veterinary
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2520353603