Work

Microvessel manifold for perfusion and media exchange in three-dimensional cell cultures

Year: 2016

Type: article

Abstract: is a substantial challenge for "on-chip" tissue models. We have developed an inclusive on-chip platform that is capable of maintaining laminar flow through porous biosynthetic microvessels. The biomimetic microfluidic device is able to deliver and generate a steady perfusion of media containing small-molecule nutrients, drugs, and gases in three-dimensional cell cultures, while replicating flow-induced mechanical stimuli. Here, we characterize the diffusion of small molecules from the perfusate, across the microvessel wall, and into the matrix of a 3D cell culture.

Source: Biomicrofluidics

DOI: 10.1063/1.4963145

Authors: Steven A. Roberts, Kyle A. DiVito, Frances S. Ligler, André A. Adams, Michael A. Daniele

Institutions: United States Naval Research Laboratory, Naval Research Laboratory Center for Bio/Molecular Science and Engineering, North Carolina State University, Lampe Joint Department of Biomedical Engineering

Language: English

Topic: 3D Printing in Biomedical Research

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: bronze