Work

Twist in the Tail: Escape from HIV Neutralising Antibodies at a Single Site Confers Broad Susceptibility to Others

Year: 2016

Type: article

Abstract: An efficacious vaccine for HIV remains elusive. Numerous groups have isolated antibodies from HIV infected individuals that can bind and neutralise antigenically diverse HIV strains, so-called broadly neutralising antibodies (bNAbs) (Wibmer et al., 2015). HIV bNAbs target several conserved regions on the viral envelope (Env; a heterotrimer composed of gp120 and gp41 subunits) including the CD4 binding site, peptidoglycan associated with either the V1/V2 or the V3 loops, and the gp120-gp41 interface or the membrane proximal external region (MPER) of gp41.

Source: EBioMedicine

DOI: 10.1016/j.ebiom.2016.09.019

Authors: Adam K Wheatley, Stephen J Kent

Institutions: The University of Melbourne, Peter Doherty Institute, Melbourne Sexual Health Centre, Alfred Health, Monash University

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,780