Work

Eukaryotic transcription initiation machinery visualized at molecular level

Year: 2016

Type: article

Abstract: The structures of RNA Polymerase (Pol) II pre-initiation complexes (PIC) have recently been determined at near-atomic resolution, elucidating unprecedented mechanistic details of promoter opening during transcription initiation. The key structural features of promoter opening are summarized here. Structural knowledge of Pol I and III PIC is also briefly discussed.

Source: Transcription

DOI: 10.1080/21541264.2016.1237150

Authors: Yan Han, Yuan He

Institution: Northwestern University

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: Chicago Community Trust, National Cancer Institute, National Institute of General Medical Sciences

Awards: G157102116, The Robert H. Lurie Comprehensive Cancer Center