Work

Disease-Associated Microbial Communities in Healthy Relatives: A Bacteria-Filled Crystal Ball?

Year: 2016

Type: article

Abstract: The bacterial community within the gastrointestinal tract has been the subject of a great deal of investigation as well as a great deal of press. Numerous studies have shown that inflammatory bowel disease (IBD) is associated with an alteration in the ecological system within our gut,1 and findings from mouse models suggest that inflammation-associated microbiota transplanted from human IBD patients can contribute actively to colitis.2 Still, it is not clear whether dysbiosis is either necessary or sufficient as an initiating event—especially in human beings—or if in contrast only a microbiome that already has been shaped by the inflammatory state is able to contribute further to disease.

Source: Cellular and Molecular Gastroenterology and Hepatology

DOI: 10.1016/j.jcmgh.2016.09.005

Author: Mark R. Frey

Institutions: University of Southern California, Children's Hospital of Los Angeles, Saban Research Institute

Language: English

Topic: Gut microbiota and health

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,430