Work

Preparation of 1,4-disubstituted-1,2,3-triazolo ribonucleosides by Na2CuP2O7 catalyzed azide-alkyne 1,3-dipolar cycloaddition

Year: 2012

Type: article

Abstract: In this study, we describe the synthesis of 1,4-disustituted-1,2,3-triazolo-ribonucleosides by means of 1,3-dipolar cycloaddition between various N-1 propargyl-pyrimidines and 1'-azido-2',3',5'-tri-O-benzoylribose catalyzed by Na2CuP2O7/sodium ascorbate.All obtained compounds were evaluated for their anti-HCV activity in vitro.

Source: ARKIVOC

DOI: 10.3998/ark.5550190.0013.807

Authors: Hanane Elayadi, Mohamed Mesnaoui, Brent E. Korba, Michael Smietana, Jean Jacques Vasseur, John A. Secrist, Hassan B. Lazrek

Institutions: Cadi Ayyad University, Georgetown University Medical Center, Institut des Biomolécules Max Mousseron, Southern Research Institute, Centre National de la Recherche Scientifique, Université Montpellier 2

Language: English

Topic: Click Chemistry and Applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funder: National Institute of Allergy and Infectious Diseases

OpenAlex ID: W2523468554

FWCI: 0.547

Cites: 1

Cited by: 15

Related to: 10