Work

Total synthesis of malagashanine: a chloroquine potentiating indole alkaloid with unusual stereochemistry

Year: 2016

Type: article

Abstract: The first total synthesis of malagashanine, a chloroquine potentiating indole alkaloid, is presented. A highly stereoselective cascade annulation reaction was developed to generate the tetracyclic core of the Malagasy alkaloids. This chemistry is likely to be broadly applicable to the synthesis of other members of this stereochemically unique family of natural products.

Source: Chemical Science

DOI: 10.1039/c6sc03578g

Authors: A. Kong, D. E. Mancheno, N. Boudet, R. Delgado, E. S. Andreansky, S. B. Blakey

Institution: Emory University

Language: English

Topic: Synthesis and bioactivity of alkaloids

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: diamond

Funders: National Science Foundation, Emory University, Division of Chemistry

Awards: G3722716624, Development of Divergent Cascade Annulation Reactions for the Synthesis of Malagashanine and Akuamilline Alkaloids