Work

Deviant Behavior: Tick-Borne Pathogens and Inflammasome Signaling

Year: 2016

Type: review

Abstract: In the face of an assault, host cells mount an immediate response orchestrated by innate immunity. Two of the best described innate immune signaling networks are the Toll- and the Nod-like receptor pathways. Extensive work has been done characterizing both signaling cascades with several recent advances on the forefront of inflammasome biology. In this review, we will discuss how more commonly-studied pathogens differ from tick-transmitted microbes in the context of Nod-like receptor signaling and inflammasome formation. Because pathogens transmitted by ticks have unique characteristics, we offer the opinion that these microbes can be used to uncover novel principles of Nod-like receptor biology.

Source: Veterinary Sciences

DOI: 10.3390/vetsci3040027

Authors: Dana Shaw, Erin McClure, Xiaowei Wang, Joao Pedra

Institution: University of Maryland, Baltimore

Language: English

Topic: Inflammasome and immune disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,534

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases