The Role of Tomato Bioactive Components and CMO2 Gene Interaction in Prostate Cancer Prevention
Year: 2012
Type: article
Abstract: Prostate cancer is one of the most common malignancies among men in the United States and is highly impacted by male hormone testosterone.The etiology of prostate cancer is complex and multifactorial.Only age has been proven to be positively associated with disease development.Testosterone signaling may interact with multiple molecular signaling axis and therefore impacts prostate biology and carcinogenesis.Epidemiological evidence has suggested an inverse association between the consumption of tomato products containing the carotenoid lycopene, and risk of prostate cancer.CMO2 enzyme has been shown to be the potential enzyme responsible for lycopene metabolism.However, how the CMO2 enzyme impacts the effects of dietary tomato carotenoids on mediating biological processes as well as counteracting prostate cancer is not clearly understood.Here, our objective was to first investigate the effects of testosterone on regulating prostate biology and p53-related signaling during early premalignancy.We then aim to examine the interactive effects of dietary tomato and testosterone actions on normal prostate biology.Lastly, we investigate the role of CMO2 enzyme in lycopene metabolism and its effects on heaptic gene expression patterns as well as prostate carcinogenesis.For the first objective, TRAMP and wild type mice were fed AIN-93G control diet.All mice were randomized to one of the four hormone treatments: Intact, Castration, Castration + Testosterone Dose 2.5 mg/Kg Body weight/Day, and Castration + tireless guidance, patience, wisdom, and kindness.Throughout the five years under his guidance, I have learned so much from him, not only the scientific knowledge, but also how to be a great scientist.He has inspired me not being afraid of setting my goals high and has taught me the essential skills to achieve them.I could not have asked for a better mentorship.I would also like to greatly thank my dissertation committee members: Dr.
Author: Tan, Hsueh-Li
Institution: The Ohio State University
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2524691336