Year: 2016
Type: review
Abstract: Advanced drug delivery systems (DDS) enhance treatment efficacy of different therapeutics in a dosage, spatial, and/or temporal controlled manner. To date, numerous chemical- or physical-based stimuli-responsive formulations or devices for controlled drug release have been developed. Among them, the emerging mechanical force-based stimulus offers a convenient and robust controlled drug release platform and has attracted increasing attention. The relevant DDS can be activated to promote drug release by different types of mechanical stimuli, including compressive force, tensile force, and shear force as well as indirect formats, remotely triggered by ultrasound and magnetic field. In this review, we provide an overview of recent advances in mechanically activated DDS. The opportunities and challenges regarding clinical translations are also discussed.
Source: Chemical Reviews
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: green
Funders: National Science Foundation, American Diabetes Association, North Carolina State University, Juvenile Diabetes Research Foundation United Kingdom, Georgia Clinical and Translational Science Alliance, National Institutes of Health, University of North Carolina at Chapel Hill, NIH Clinical Center, Division of Engineering Education and Centers, Division of Emerging Frontiers in Research and Innovation, National Center for Advancing Translational Sciences, North Carolina Translational and Clinical Sciences Institute, University of North Carolina at Chapel Hill
Awards: G1046751283, G1090138688, Bio-Inspired Synthetic Pathway for Closed-Loop Delivery of Insulin and Glucagon, G2199178042, G2731946366, North Carolina Translational & Clinical Sciences Institute (NC TraCS), G4469737694, G4792645583, NSF Nanosystems Engineering Research Center for Advanced Self-Powered Systems of Integrated Sensors and Technologies (ASSIST), G5573525031, EFRI-ODISSEI: Externally-Triggered Origami of Responsive Polymer Sheets, G7178678552, G7217447086, G7625901119
OpenAlex ID: W2525539600