Year: 2016
Type: review
Abstract: - It is well accepted that age is an important contributing factor to poor cartilage repair following injury, and to the development of osteoarthritis. Cellular senescence, the loss of the ability of cells to divide, has been noted as the major factor contributing to age-related changes in cartilage homeostasis, function, and response to injury. The underlying mechanisms of cellular senescence, while not fully understood, have been associated with telomere erosion, DNA damage, oxidative stress, and inflammation. In this review, we discuss the causes and consequences of cellular senescence, and the associated biological challenges in cartilage repair. In addition, we present novel strategies for modulation of cellular senescence that may help to improve cartilage regeneration in an aging population.
Source: Acta Orthopaedica
Institutions: National University of Singapore, Life Sciences Institute, University of Gothenburg, Indiana University School of Medicine, Aarhus University Hospital, Brigham and Women's Hospital, Harvard University, National University Health System, Robert Jones and Agnes Hunt Orthopaedic Hospital, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust, Keele University, VA Boston Healthcare System
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,779
OpenAlex ID: W2526169494