CD36 Provides Host Protection AgainstKlebsiella pneumoniaeIntrapulmonary Infection by Enhancing Lipopolysaccharide Responsiveness and Macrophage Phagocytosis
Year: 2016
Type: article
Abstract: Klebsiella pneumoniae remains an important cause of intrapulmonary infection and invasive disease worldwide. K. pneumoniae can evade serum killing and phagocytosis primarily through the expression of a polysaccharide capsule, but its pathogenicity is also influenced by host factors. We examined whether CD36, a scavenger receptor that recognizes pathogen and modified self ligands, is a host determinant of K. pneumoniae pathogenicity. Despite differences in serum sensitivity and virulence of 3 distinct K. pneumoniae (hypermucoviscous K1, research K2, and carbapenemase-producing ST258) strains, the absence of CD36 significantly increased host susceptibility to acute intrapulmonary infection by K. pneumoniae, regardless of strain. We demonstrate that CD36 enhances LPS responsiveness to K. pneumoniae to increase downstream cytokine production and macrophage phagocytosis that is independent of polysaccharide capsular antigen. Our study provides new insights into host determinants of K. pneumoniae pathogenicity and raises the possibility that functional mutations in CD36 may predispose individuals to K. pneumoniae syndromes.
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Awards: G1342907914, Regulation of the interferon lamda receptor by influenza, G2463347453, G2506595212, G3180420289, Stabilizing mitochondria in sepsis, Enhancing Neutrophil Responses to Counter MDR Gram Negative Bacterial Pneumonia, A New Genus of Ubiquitin-Based Anti-inflammatories for COPD, G9000002626, G9000200037, Sepsis-Associated Immune Suppression and F-box Proteins
OpenAlex ID: W2526547671