Work

Regulating Stem Cell Secretome Using Injectable Hydrogels with In Situ Network Formation

Year: 2016

Type: article

Abstract: A family of shear-thinning hydrogels for injectable encapsulation and long-term delivery (SHIELD) has been designed and synthesized with controlled in situ stiffening properties to regulate the stem cell secretome. The authors demonstrate that SHIELD with an intermediate stiffness (200-400 Pa) could significantly promote the angiogenic potential of human adipose-derived stem cells.

Source: Advanced Healthcare Materials

DOI: 10.1002/adhm.201600497

Authors: Lei Cai, Ruby E. Dewi, Andrew B. Goldstone, Jeffrey E. Cohen, Amanda N. Steele, Y. Joseph Woo, Sarah C. Heilshorn

Institutions: Stanford University, Stanford Medicine

Language: English

Topic: Hydrogels: synthesis, properties, applications

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Biomedical Imaging and Bioengineering

Awards: G1458265168, Design of injectable hydrogels to improve cell transplantation for peripheral arterial disease

OpenAlex ID: W2528773293

FWCI: 3.264

Cites: 43

Cited by: 61

Related to: 10