Episodic memory of odors stratifies Alzheimer biomarkers in normal elderly
Year: 2016
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: The objective of this study was to relate a novel test of identifying and recalling odor percepts to biomarkers of Alzheimer's disease (AD) in well-characterized elderly individuals, ranging from cognitively normal to demented. METHODS: One hundred eighty-three participants (cognitively normal: n = 70; subjective cognitive concerns: n = 74; mild cognitive impairment [MCI]: n = 29, AD dementia: n = 10) were administered novel olfactory tests: the Odor Percept IDentification (OPID) and the Percepts of Odor Episodic Memory (POEM) tests. Univariate cross-sectional analyses of performance across diagnoses; logistic regression modeling, including covariates of age, sex, education, APOE genotype, and neuropsychological test scores; and linear mixed modeling of longitudinal cognitive scores were performed. Amyloid deposition and MRI volumetrics were analyzed in a subset of participants. RESULTS: Accuracy of identification and episodic memory of odor percepts differed significantly across diagnosis and age, with progressively worse performance across degrees of impairment. Among the participants who were cognitively normal or had subjective cognitive concerns, poorer than expected performance on the POEM test (based on the same individual's performance on the OPID and odor discrimination tests) was associated with higher frequencies of the APOE ε4 allele, thinner entorhinal cortices, and worse longitudinal trajectory of Logical Memory scores. INTERPRETATION: Selective impairment of episodic memory of odor percepts, relative to identification and discrimination of odor percepts revealed by this novel POEM battery, is associated with biomarkers of AD in a well-characterized pre-MCI population. These affordable, noninvasive olfactory tests offer potential to identify clinically normal individuals who have greater likelihood of future cognitive decline. Ann Neurol 2016;80:846-857.
Source: Annals of Neurology
DOI: 10.1002/ana.24792
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Propagation of Neurodegeneration by Innate Immune Pattern Recognition Receptors In Vivo, The Olfactory Neural Circuit as a systems Level Model of Neurodegenerative Diseas, Mentoring Imaging Research in Early AD, Faculty recruitment for programs in the biology of age-related cognitive change, Physiologic Mechanisms of Action of APP and APLP2 in Axon Targeting, Massachusetts Alzheimer's Disease Research Center, Center for Alzheimer Therapeutic Science: CATS, Training in Neurostatistics and Neuroepidemiology, G9000208643, Impact of Amyloid and Tau on the Aging Brain: The Harvard Aging Brain Study
OpenAlex ID: W2528829488