Year: 2012
Type: article
Abstract: Infection by human immunodeficiency virus (HIV) promotes neurological alterations which are more severe and frequents, due to the aging of the population. This dementia is associated to neuronal disfunction, and is pathologicaly characterized as sinapse lose, dendritic abnormalities and neuronal death. Supporting this, several studies have shown a significant increase of the amyloid plaques in infected HIV brains compared to healthy controls as well as HIV positive individuals which were exposed to antiretroviral therapy. In the present study we have investigated the combined effect of amyloid-β and HIV-1 infection in diferent nervous cells. When we pretreated glial cells and neurons we found an increased viral replication, as well as the combined treatment of HIV and oligomeric and fibrils forms of amyloid-β which produce glial increased levels of oxygen reactive species and the proapoptotic enzyme caspase-3. These observations could be traduced in an increased neurotoxicity and amyloid-β deposits in infected brains.
Authors: R González, S Álvarez, MA Muñoz-Fernández
Institution: Hospital General Universitario Gregorio Marañón
Language: Spanish
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W2025799644