Year: 2016
Type: article
Abstract: Immunosurveillance requires the migration of lymphocytes and their activation to induce proliferation and effector function. Effective immunity requires an optimal supply of nutrients to lymphocytes. Cells contain nutrient sensing apparatus such as adenosine 5'-monophosphate-activated protein kinase (AMPK) that surveys intracellular ATP levels. Immunity declines during ageing and one possibility is that the energy balance may be altered in old lymphocytes. This paper summarizes recent data identifying a convergence of senescence and nutrient signalling pathways in lymphocytes that inhibit both T cell and natural killer (NK) cell function during ageing. Significantly, these pathways can be inhibited to enhance the activity of these cells.
DOI: 10.1111/cei.12876
Author: A N Akbar
Institution: University College London
Language: English
Subfield: Aging
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $1,878
Awards: New technology to study T lymphocyte ageing in vitro and in vivi, Telomerase downregulation in memory CD8+ T cells by cytokine and surface inhibitory receptor signalling, G5026352069, MICA: Suppressing inflammation to enhance antigen-specific immunity in older humans using p38MAPK inhibitors and vitaminD3, Reversing senescence and exhaustion signalling pathways in primary human T lymphocytes during ageing
OpenAlex ID: W2529290665