Work

Senescence of T Lymphocytes: Implications for Enhancing Human Immunity

Year: 2016

Type: review

Source: Trends in Immunology

DOI: 10.1016/j.it.2016.09.002

Authors: Arne N. Akbar, Sian M. Henson, Alessio Lanna

Institutions: University College London, Queen Mary University of London, William Harvey Research Institute, University of Oxford

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: Wellcome Trust, Academy of Medical Sciences, Medical Research Council, Biotechnology and Biological Sciences Research Council

Awards: Metabolic control of T cell receptor signalling, The functional and migratory characteristics of low avidity virus-specific T cells during ageing, New technology to study T lymphocyte ageing in vitro and in vivi, Telomerase downregulation in memory CD8+ T cells by cytokine and surface inhibitory receptor signalling, G5026352069, MICA: Suppressing inflammation to enhance antigen-specific immunity in older humans using p38MAPK inhibitors and vitaminD3, G5994324655, Reversing senescence and exhaustion signalling pathways in primary human T lymphocytes during ageing, G6873689941, International Partnering Award with the USA to investigate signalling pathways that regulate human immunity during ageing, Mechanisms of reduced T cell imunity in older adults

OpenAlex ID: W2529494470

FWCI: 1.691

Cites: 81

Cited by: 293

Related to: 10