Year: 2016
Type: review
Abstract: Ageing is a process that gradually increases the organism's vulnerability to death. It affects different biological pathways, and the underlying cellular mechanisms are complex. In view of the growing disease burden of ageing populations, increasing efforts are being invested in understanding the pathways and mechanisms of ageing. We review some mouse models commonly used in studies on ageing, highlight the advantages and disadvantages of the different strategies, and discuss their relevance to disease susceptibility. In addition to addressing the genetics and phenotypic analysis of mice, we discuss examples of models of delayed or accelerated ageing and their modulation by caloric restriction.
Institutions: Estonian University of Life Sciences, University of Tartu, Yeditepe University, Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas, Centro de Investigación Biomédica en Red, INCLIVA Health Research Institute, Mary Lyon Centre at MRC Harwell, Ghent University, VIB-UGent Center for Inflammation Research
Language: English
Subfield: Aging
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,780
Funder: Austrian Science Fund
OpenAlex ID: W2529858651