Toxicological Effect of Ethanolic Extract of Cannabis sativa on Brain Serotonin in Adult Wistar Rats
Year: 2016
Type: article
Abstract: Studies have identified that Cannabis sativa (Marijuana) has been used recreationally and medicinally, this has resulted in an increase in the consumption of Cannabis sativa among young people. The aim of this study is to produce data on toxicological effect of ethanolic extract of Cannabis sativa on serotonin concentration and tissue histopathology in the brain of adult wistar rats. Rats were divided into 3 groups with each group consisting of 8 rats. Treated groups received ethanolic extract of Cannabis sativa 25mg/kg body weight and 10% ethanol. The treatments were administered orally within two weeks for short duration and five weeks for long duration. The brain tissues were used for histological assay; the brain serotonin level was determined. Results showed a significant alteration in the level of brain serotonin at two and five weeks administration compared to the control group. Histopathological alterations were also observed.
Source: American Journal of Biochemistry
Language: English
Subfield: Pharmacology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2530330675