Year: 2013
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: To identify correlates and longitudinal changes in circulating antimüllerian hormone (AMH) levels as a marker of ovarian primordial follicle recruitment in normal peripubertal girls. DESIGN: Observational study using mixed longitudinal and cross-sectional analyses. SETTING: Not applicable. PATIENT(S): Unselected girls assessed at ages 7-11 years. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): AMH, inhibin B, and FSH levels were analyzed in blood samples collected at ages 7, 9, and 11 years for longitudinal analyses and at age 8 years for cross-sectional analyses. RESULT(S): In the cross-sectional analysis, AMH levels at age 8 years were lower in pubertal girls (median 25.0 pmol/L, interquartile range [IQR] 16.0-33.9; n = 39) than in prepubertal girls (33.5 pmol/L, IQR 22.3-49.1; n = 342). In prepubertal girls, higher AMH levels were associated with higher inhibin B levels, lower FSH levels, and larger body mass index at age 8 years and subsequently with later age at menarche. AMH levels were unrelated to birth weight or birth length. In the longitudinal analysis, AMH levels increased between ages 7 (median 27.0 pmol/L, IQR 19.2-34) and 9 years (32.0 pmol/L, IQR 26.5-42.7), then declined between 9 and 11 years (26.5 pmol/L, IQR 19-42.25) with high intraindividual correlation in AMH levels between ages 7 and 9 years and 7 and 11 years. CONCLUSION(S): Measurement of circulating AMH and inhibin B levels suggests that the rate of ovarian primordial follicle recruitment increases in the prepubertal years then declines again following the onset of puberty as follicular activity pattern changes.
Source: Fertility and Sterility
Authors: Hany Lashen, David B. Dunger, Andy Ness, Ken K. Ong
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,220
Awards: G1153816297, G1659787205, ALSPAC: consolidation of a two generation cell line backed resource, for the study of the environment and genetic determinants of health and development from before birth to late puberty., G1924190148, G2179969359, G3946348556, The Avon Longitudinal Study of Parents and Children: An international resource for population genomics and lifecourse epidemiology. Core Programme Support 2011-2013., G7042387311, Child Growth and development
OpenAlex ID: W1966881991