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The circadian coordination of cell biology

Year: 2016
Type: review
Abstract: Circadian clocks are cell-autonomous timing mechanisms that organize cell functions in a 24-h periodicity. In mammals, the main circadian oscillator consists of transcription-translation feedback loops composed of transcriptional regulators, enzymes, and scaffolds that generate and sustain daily oscillations of their own transcript and protein levels. The clock components and their targets impart rhythmic functions to many gene products through transcriptional, posttranscriptional, translational, and posttranslational mechanisms. This, in turn, temporally coordinates many signaling pathways, metabolic activity, organelles' structure and functions, as well as the cell cycle and the tissue-specific functions of differentiated cells. When the functions of these circadian oscillators are disrupted by age, environment, or genetic mutation, the temporal coordination of cellular functions is lost, reducing organismal health and fitness.
DOI: 10.1083/jcb.201603076
Language: English
Open Access status: green
Funders: American Diabetes Association, American Federation for Aging Research, Glenn Foundation for Medical Research, American Association for the Study of Liver Diseases, Leona M. and Harry B. Helmsley Charitable Trust, National Institutes of Health, National Eye Institute, National Institute of Diabetes and Digestive and Kidney Diseases
Awards: Circadian Photoentrainment in Mammals, G198914242, Cross-talk between the circadian clock and the cAMP signaling pathway, G6446969811, The Relationship of Gut Microbiome and Time Restricted Feeding in Metabolism, G7008760859, Training Grant in Gastroenterology, G819730897, G9000034313
OpenAlex ID: W2530840165
FWCI: 1.382
Cites: 109
Cited by: 159
Related to: 10