Work

Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex

Year: 2016

Type: article

Source: Molecular Cell

DOI: 10.1016/j.molcel.2016.09.009

Authors: Tian-Min Fu, Yang Li, Alvin Lu, Zongli Li, Parimala R. Vajjhala, Anthony C. Cruz, Devendra B. Srivastava, Frank DiMaio, Pawel A. Penczek, Richard M. Siegel, Katryn J. Stacey, Edward H. Egelman, Hao Wu

Institutions: Boston Children's Hospital, Harvard University, Howard Hughes Medical Institute, The University of Queensland, National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases, University of Washington, Texas Medical Center, The University of Texas Health Science Center at Houston, Institute for Molecular Bioscience, University of Virginia

Language: English

Topic: Cell death mechanisms and regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: National Institutes of Health, National Health and Medical Research Council, National Medical Research Council, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Institute of Biomedical Imaging and Bioengineering, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: Structural & Functional Studies of TLR/IL-1R Signaling, SMOCs: Novel Signal Transduction Complexes as New Targets for Drug Discovery, G4789071022, G4817476567, Structural and functional elucidation of the necrosome in innate immune signaling, G8885647446

OpenAlex ID: W2531084658

FWCI: 7.375

Cites: 48

Cited by: 194

Related to: 10