Oropharyngeal candidiasis and antifungal assessment of Candida glabrata in patients with HIV infection
Year: 2016
Type: article
Study design: Observational Study
Abstract: The purposes of this study were to determine the prevalence of oral mycoflora in HIV + patients and to assay antifungal susceptibility profile of Candida glabrata (C.glabrata) isolates to standard antifungal agents.A total of 100 HIV-infected patients with oropharyngeal candidiasis (OPC) were selected in this study.Susceptibility of C. glabrata isolates to antifungals was determined using the disc diffusion method.A total of 254 yeasts were isolated from the patients.Forty percent (40%) of the patients had angular cheilitis as the most frequent clinical variant.Candida species (94.4%) were the most frequently obtained genera (P<0.05),followed by Saccharomyces (2.4%), Kluyveromyces and Cryptococcus (1.6%) species.C. albicans (37.2%) was the most common species isolated from HIV + patients with OPC and its frequency was significantly higher than that of other Candida species (P<0.05).Among non-C.albicans species, C. glabrata was the most frequent species.Highest sensitivity of C. glabrata to antifungal drugs was seen against polyene drugs such as nystatin and amphotericin B. This study revealed huge diversity of Candida species and oral isolates of C. glabrata were most sensitive to polyene drugs such as nystatin and amphotericin B and least sensitive to fluconazole.
Authors: A. Sharifzadeh, H. Shokri
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Funder: University of Tehran
OpenAlex ID: W2409325600