Work

Design of Hydrated Porphyrin-Phospholipid Bilayers with Enhanced Magnetic Resonance Contrast

Year: 2016

Type: article

Abstract: Computer simulations are used to design more hydrated bilayers, formed from amine-modified porphyrin-phospholipids (PoPs). Experiments confirm that the new constructs give rise to bilayers with greater water content. When chelated with manganese, amine-modified PoPs provide improved contrast for magnetic resonance and are safely used for imaging in vivo.

Source: Small

DOI: 10.1002/smll.201602505

Authors: Shuai Shao, Trang Nhu Do, Aida Razi, Upendra Chitgupi, Jumin Geng, Richard J. Alsop, Boris G. Dzikovski, Maikel C. Rheinstädter, Joaquin Ortega, Mikko Karttunen, Joseph A. Spernyak, Jonathan F. Lovell

Institutions: University at Buffalo, State University of New York, University of Waterloo, Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Cornell University, Eindhoven University of Technology, Roswell Park Comprehensive Cancer Center

Language: English

Topic: Porphyrin and Phthalocyanine Chemistry

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

Open Access status: green

Funders: National Science Foundation, National Institutes of Health, University at Buffalo, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Biomedical Imaging and Bioengineering, National Center for Advancing Translational Sciences

Awards: Chemophototherapy with Porphyrin-phospholipid Liposomes Permeabilized by Red Light, Targeting Tumors with Resealable Nanovesicles Permeabilized by NIR Light, University of Buffalo Clinical and Translational Science Institute, National Biomedical Center for Advanced ESR Technology (ACERT), Roswell Park Cancer Center Support Grant

OpenAlex ID: W2531105097

FWCI: 1.483

Cites: 43

Cited by: 25

Related to: 10