Year: 2016
Type: review
Abstract: When the MESA (Multi-Ethnic Study of Atherosclerosis) began, the Framingham risk score was the preferred tool for 10-year global coronary heart disease risk assessment; however, the Framingham risk score had limitations including derivation in a homogenous population lacking racial and ethnic diversity and exclusive reliance on traditional risk factors without consideration of most subclinical disease measures. MESA was designed to study the prognostic value of subclinical atherosclerosis and other risk markers in a multiethnic population. In a series of landmark publications, MESA demonstrated that measures of subclinical cardiovascular disease add significant prognostic value to the traditional Framingham risk variables. In head-to-head studies comparing these markers, MESA established that the coronary artery calcium score may be the single best predictor of coronary heart disease risk. Results from MESA have directly influenced recent prevention guidelines including the recommendations on risk assessment and cholesterol-lowering therapy. The MESA study has published its own risk score, which allows for the calculation of 10-year risk of coronary heart disease before and after knowledge of a coronary artery calcium score.HighlightsThe MESA (Multi-Ethnic Study of Atherosclerosis) is the first National Heart, Lung, and Blood Institute cohort dedicated to the study of subclinical cardiovascular disease, including its predictors, progression, and influence on outcomes.MESA has demonstrated that coronary artery calcium significantly adds risk predictive value beyond traditional risk factors.MESA has directly influenced recommendations in the new 2013 American College of Cardiology/American Heart Association prevention guidelines, including risk prediction and the treatment of blood cholesterol.MESA recently published the first 10-year risk score incorporating both coronary artery calcium and risk factors.
Source: Global Heart
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,300
Funders: American Heart Association, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute on Drug Abuse, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources, National Center for Advancing Translational Sciences
Awards: Individual response to vitamin D treatment, Subclinical Renal Artery Atherosclerosis, Kidney Function and Hypertension, Epidemiology of Vascular Inflammation & Atherosclerosis, Endogenous Anti-Inflammatory Lipid Mediators, Fish Oil and Post-Operative Atrial, G399481048, TITLE: MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA), Abdominal Body Composition, Inflammation and Cardiovascular Diseaase, Serum Sex Hormone Levels and Subclinical Atherosclerosis, Multi-Scale Biology of Atherosclerosis in the Cellular Adhesion Pathway, Serum Sex Hormonoe Levels & Subclinical Atherosclerosis, Genome-wide and Linkage Study of Quantitative Emphysema Phenotypes, Institute for Clinical and Translational Research, G6709113048, Fetuin-A: A Novel Biomarker of Vascular Calcification and Diabetes Mellitus, Regional Dysfunction by MRI in Incident Heart Failure, Socioeconimic Patterning of Inflammation and Hemostasis, Endothelial Dysfunction and the RV in the Multi-Ethnic Study of Atherosclerosis, Clinical and Translational Science Award, Combined Cardiopulmonary Failure in COPD: SPIROMICS HF, Precision phenotyping of emphysema in the elderly: the MESA Lung Study, Tools for Measuring and Analyzing Cortisol Levels in Population Studies of Health
OpenAlex ID: W2531506143