Work

Checkpoints for preliminary identification of small molecules found enriched in autophagosomes and activated mast cell secretions analyzed by comparative UPLC/MS e

Year: 2016

Type: article

Abstract: fragmentation. The importance of this second checkpoint was highligthed through validation with selected commercially available standards. This work illustrates that checkpoints in data processing are essential to ascertain reliability of unbiased metabolomic studies, thereby reducing the risk of generating 'false identifications' which are is a major concern as 'omics' data continue to proliferate and be used as platforms to lauch novel biological hypotheses.

Source: Analytical Methods

DOI: 10.1039/c6ay02500e

Authors: Chad P. Satori, Marzieh Ramezani, Joseph S. Koopmeiners, Audrey F. Meyer, Jose A. Rodriguez-Navarro, Michelle M. Kuhns, Thane H. Taylor, Christy L. Haynes, Joseph J. Dalluge, Edgar A. Arriaga

Institutions: University of Minnesota, Albert Einstein College of Medicine

Language: English

Topic: Metabolomics and Mass Spectrometry Studies

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute on Aging, NIH Office of the Director, National Cancer Institute, National Institute of General Medical Sciences

Awards: G1030671108, Training for Future Biotechnology Development, G2915001239, G3174314898, G3997793491, G4663094367, Autophagy in aging: testing geroscience in Alzheimer's disease, G6375243110, Interplay between lipophagy and mitophagy in skeletal muscle aging, Thermodynamics of Gelation and Dynamic Properties of Biosynthetic Hydrogels, Chemistry-Biology Interface Training Grant, IMMUNE SYSTEM-ON-A-CHIP FOR QUANTITATIVE ANALYSIS OF CELL INTERACTIONS DURING ALL, Cancer Center Support Grant

OpenAlex ID: W2531764895

FWCI: 0.173

Cites: 58

Cited by: 2

Related to: 10