Biomarkers of Key Biological Pathways in CVD
Year: 2016
Type: review
Abstract: This review provides background on the laboratory design for MESA (Multi-Ethnic Study of Atherosclerosis) as well as the approach used in MESA to select biomarkers for measurement. The research related to the multitude of circulating and urinary biomarkers of inflammation and other novel and emerging biological pathways in MESA is summarized by domain, or pathway, represented by the biomarker. The contributions of MESA biomarkers to our knowledge of these key pathways in the development and progression of atherosclerosis, cardiovascular disease, diabetes, kidney disease, and pulmonary disease are highlighted, as are the contributions of MESA to recommendations for clinical use of several of these biomarkers. In addition, contributions of MESA to multicohort genomics consortia and current collaborations in transomics and metabolomics are noted.HighlightsMESA (Multi-Ethnic Study of Atherosclerosis) has measured over 180 circulating and urinary biomarkers of inflammation and other novel and emerging specific biological pathways.Pathways include inflammation, insulin resistance, lipids and fatty acids, hemostasis and fibrinolysis, renal function, renin-angiotensin-aldosterone system, adipokines, atherosclerotic plaque stability, endothelial cell function, oxidative damage, vitamins and minerals, chronic infection, sex hormones, cardiac function, and immune cell profiles.These biomarkers have contributed to over 1,000 research articles and many clinical recommendations.Biomarker measurements are also being utilized in multicohort consortia examining genomics, transomics, and metabolomics.
Source: Global Heart
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,300
Funders: American Heart Association, GlaxoSmithKline, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute on Drug Abuse, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources, National Center for Advancing Translational Sciences
Awards: G1085777395, G1109825509, G1156594538, G1261793039, MESA, G1276754516, G1286721212, Individual response to vitamin D treatment, G1409423729, G1483344193, G1497137905, G1508998135, G1640378483, Subclinical Renal Artery Atherosclerosis, Kidney Function and Hypertension, G1686417863, G1747129958, G1922428914, Epidemiology of Vascular Inflammation & Atherosclerosis, G2144938473, G2215959655, G22458031, G2262782284, G2391309017, MESA, G2432508282, G2545476352, G2600980409, Endogenous Anti-Inflammatory Lipid Mediators, Fish Oil and Post-Operative Atrial, G270112351, MESA, G2837638605, G283874107, G290884426, G291913881, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--EBCT READING, G3106377335, G350785449, G3581052147, G3639969904, G3647016462, G3667269547, G3687594596, MESA, REGULATORY LIGHT CHAIN AND MYOCARDIAL CONTRACTION, G3966146196, G399481048, G4013255670, TITLE: MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA), G4401650913, G4498746773, G4512137732, G4678087642, G4824239441, OPTION 3. 4/1/2014 - 3/31/2015. MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA) - READING CENTER, NHLBI, MESA, G496640596, Abdominal Body Composition, Inflammation and Cardiovascular Diseaase, Serum Sex Hormone Levels and Subclinical Atherosclerosis, G5088122703, G5108002584, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-ULTRASOUND, G5324596834, G5605591545, Multi-Scale Biology of Atherosclerosis in the Cellular Adhesion Pathway, G5787256936, G6095866717, G611940047, G6154286948, Serum Sex Hormonoe Levels & Subclinical Atherosclerosis, G6217957645, Genome-wide and Linkage Study of Quantitative Emphysema Phenotypes, G6359107525, G6372296772, Institute for Clinical and Translational Research, MESA, G6514094751, G658953780, G66341962, G6933680662, Fetuin-A: A Novel Biomarker of Vascular Calcification and Diabetes Mellitus, Ambulatory BP, kidney function, cognitive & physical function in older adults, G713258703, G7140792677, G7196194893, MESA, Regional Dysfunction by MRI in Incident Heart Failure, G7608066430, Socioeconimic Patterning of Inflammation and Hemostasis, G7706274302, G7781832098, Endothelial Dysfunction and the RV in the Multi-Ethnic Study of Atherosclerosis, G78770644, G805458286, Clinical and Translational Science Award, G813377844, G8284255050, G867112777, G8781465314, Combined Cardiopulmonary Failure in COPD: SPIROMICS HF, Precision phenotyping of emphysema in the elderly: the MESA Lung Study, G991334795
OpenAlex ID: W2531882797