Work

Helixconstraints and amino acid substitution in GLP-1 increase cAMP and insulin secretion but not beta-arrestin 2 signaling

Year: 2016

Type: article

Source: European Journal of Medicinal Chemistry

DOI: 10.1016/j.ejmech.2016.10.044

Authors: Fabien Plisson, Timothy A. Hill, Justin M. Mitchell, Huy N. Hoang, Aline D. de Araujo, Weijun Xu, Adam Cotterell, David J. Edmonds, Robert V. Stanton, David R. Derksen, Paula M. Loria, David A. Griffith, David A. Price, Spiros Liras, David P. Fairlie

Institutions: The University of Queensland, Institute for Molecular Bioscience, Pfizer (United States)

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: Pfizer, Queensland Government, Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Australian Research Council, National Health and Medical Research Council, National Medical Research Council

Awards: Innovations in peptide-based drug design, Downsizing proteins to equipotent small molecules that activate cells

OpenAlex ID: W2532039124

FWCI: 1.385

Cites: 63

Cited by: 26

Related to: 10