IC‐P‐134: Differentiating Preclinical Alzheimer’s Disease from Normal Aging: The Effects of Age and Amyloid on Cognitive Decline Over 3.5 Years
Year: 2016
Type: article
Abstract: shift integral (MAPS-HBSI) -were calculated.The 264 patients in the ADNI1 study with BTB 1.5T MPRAGE MRIs at baseline, year 1 and year 3 were used.The BTB reproducibility of the atrophy rate of both the left and right hippocampus over 1 year and 3 years were compared with a simple statistical test based on the binomial sign test that handled outlying data points robustly.Results: The noise in the atrophy rate, as measured by the reproducibility in units of percentage points, showed no statistical difference between 1 and 3 years in 4 of the 5 methods.FSL/FIRST was slightly noisier in both hippocampi over 1 year than 3 years (p¼0.002& p¼0.002).For example, the noise for the left hippocampus for FreeSurfer longitudinal was 2.0% over 1 year and 2.2% over 3 years while the corresponding atrophy rates were 1.9% and 5.2%.Conclusions: The noise of measuring hippocampal atrophy rates over 3 years was no worse than over 1 year for the 5 methods studied.Therefore, if the atrophy rate was stable over the 3 years, the 3 year study would be at least 3 times as sensitive as the 1 year study to changes in atrophy rate.
Source: Alzheimer s & Dementia
Authors: Michelle E. Farrell, Kristen M. Kennedy, Karen M. Rodrigue, Gagan S. Wig, Gérard N. Bischof, Jennifer R. Rieck, Xi Chen, Sara B. Festini, Michael D. Devous, Denise C. Park
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2532052557