Year: 2015
Type: article
Abstract: Conditioned pain modulation (CPM), also termed as the diffuse noxious inhibitory controls (DNIC), is a kind of endogenous pain inhibitory modulation. It refers to the physiological phenomenon that subjective perception of a nociceptive stimulus (i.e., test stimulus) can be suppressed by another painful stimulus (i.e., conditioning stimulus) delivered to a body area far away from the stimulus site of test stimulus. Individual CPM efficiency is defined as the conditioning stimulus induced suppression of subjective pain perception of the test stimulus. Previous studies have showed that many types of chronic pain patients are characterized as deficts of CPM function, and CPM efficiency of patients could even predict the risk of developing chronic pain, suggesting possible clincial applications of CPM. However, since the underlying mechanisms of CPM are still not very clear, various factors could influence individual CPM efficiency, and the approaches of evaluting CPM effiency are even not consistent, the applications of CPM in clincial practice are limited and sluggish. For a better understanding of CPM process and an advancement CPM-related clincial applications, the current review thus intensively and comprehensively summarized and discussed the mechansims, measurements, determinants, and applications of CPM.
Authors: Yi TANG, Li HU, DanDan TANG, WeiWei PENG
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2532362240