Differential effects of mutant TAp63γ on transactivation of p53 and/or p63 responsive genes and their effects on global gene expression
Year: 2007
Type: article
Abstract: Differential effect of TAp63γ mutants on transactivation of p53 and/or p63 responsive genes and their effects on global gene expression.p63, a member of the p53 gene family, known to play a role in development, has more recently also been implicated in cancer progression.Mice lacking p63 exhibit severe developmental defects such as limb truncations, abnormal skin, and absence of hair follicles, teeth, and mammary glands.Germline missense mutations of p63 have been shown to be responsible for
Author: Shama Khokhar
Institution: Wright State University
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2533102915