Work

Valproic Acid Exposure during Early Postnatal Gliogenesis Leads to Autistic-like Behaviors in Rats

Year: 2016

Type: article

Abstract: OBJECTIVE: We reported that postnatal exposure of rats to valproic acid (VPA) stimulated proliferation of glial precursors during cortical gliogenesis. However, there are no reports whether enhanced postnatal gliogenesis affects behaviors related to neuropsychiatric disorders. METHODS: After VPA treatment during the postnatal day (PND) 2 to PND 4, four behavioral test, such as open field locomotor test, elevated plus maze test, three-chamber social interaction test, and passive avoidance test, were performed at PND 21 or 22. RESULTS: <0.05). CONCLUSION: Our results suggest that altered glial cell development is another locus at which pathogenetic factors can operate to contribute to the neurodevelopmental disorder.

Source: Clinical Psychopharmacology and Neuroscience

DOI: 10.9758/cpn.2016.14.4.338

Authors: Tamanna Jahan Mony, Jae Won Lee, Cheryl Dreyfus, Emanuel DiCicco-Bloom, Hee Jae Lee

Institutions: Kangwon National University, Korea Research Institute of Bioscience and Biotechnology, Rutgers, The State University of New Jersey

Language: English

Topic: Autism Spectrum Disorder Research

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Kangwon National University, Eunice Kennedy Shriver National Institute of Child Health and Human Development