Work

Genetic engineered molecular imaging probes for applications in cell therapy: emphasis on MRI approach.

Year: 2016

Type: article

Abstract: . We begin this review with an introduction describing the progress in stem cell technology, with a perspective toward cell replacement therapy. The importance of molecular imaging in reporting and assessing the status of cell grafts and their relation to the local microenvironment is highlighted since the current knowledge gap is one of the major obstacles in clinical translation of stem cell therapy. Based on currently available imaging techniques, we provide a brief discussion on the pros and cons of each imaging modality used for monitoring cell grafts with particular emphasis on magnetic resonance imaging (MRI) and the reporter gene approach. Finally, we conclude with a comprehensive discussion of future directions of applying molecular imaging in regenerative medicine to emphasize further the importance of correlating cell graft conditions and clinical outcomes to advance regenerative medicine.

Source: Europe PMC (PubMed Central)

Authors: In K Cho, Silun Wang, Hui Mao, Anthony Ws Chan

Institutions: Emory University, Emory National Primate Research Center

Language: English

Topic: Mesenchymal stem cell research

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Neurological Disorders and Stroke

Awards: MONITORING STEM CELL GRAFTS USING A NOVEL MRI REPORTER, Emory National Primate Research Center