Work

Erythropoietin modulation is associated with improved homing and engraftment after umbilical cord blood transplantation

Year: 2016

Type: article

Abstract: cells, an effect that was overcome with exogenous EPO administration. Of clinical relevance, HBO therapy before human UCB transplantation was well-tolerated and resulted in transient reduction in EPO with encouraging engraftment rates and kinetics. Our studies indicate that systemic reduction of EPO levels in the host or blocking EPO-EPOR signaling may be an effective strategy to improve BM homing and engraftment after allogeneic UCB transplantation. This clinical trial was registered at www.ClinicalTrials.gov (#NCT02099266).

Source: Blood

DOI: 10.1182/blood-2016-05-715292

Authors: Omar S. Aljitawi, Soumen Paul, Avishek Ganguly, Tara L. Lin, Sid Ganguly, George Vielhauer, Maegan L. Capitano, Amy Cantilena, Brea Lipe, Jonathan D. Mahnken, Amanda Wise, Abigale Berry, Anurag K. Singh, Leyla Shune, Christopher Lominska, Sunil Abhyankar, Dennis Allin, Mary Laughlin, Joseph P. McGuirk, Hal E. Broxmeyer

Institutions: University of Rochester Medicine, University of Kansas Medical Center, University of Rochester, Indiana University Indianapolis, Indiana University School of Medicine, Cleveland Cord Blood Center, Case Western Reserve University

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: G1314050122, Chemotherapy resistance in ALL: role of the bone marrow microenvironment, Novel Approaches for the Control of Microbial Pathogens, Regulation of Hematopoietic Cell Production, Enhancing Engraftment of Cord Blood by CD26 Inhibition, Hematopoietic stem and progenitor cell regulation for enhanced clinical efficacy

OpenAlex ID: W2536636502

FWCI: 6.019

Cites: 21

Cited by: 40

Related to: 10